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Exclusive interview / Dr. Anton Titov MD and Professor Dr. Paul Matthews, leading multiple sclerosis neurologist, neurodegeneration, brain imaging MRI, functional MRI, PET expert and precision medicine specialist.
Neurology disease treatment is very costly and often is not as efficient as it can be. You have advanced the concept of "Stratified Medicine" to improve quality of clinical care for patients with neurological disease. What is Stratified Medicine concept? How does it help in clinical management of neurological diseases, including multiple sclerosis? The concept of stratified medicine is that all patients are not alike, and that some groups of patients who carry a common diagnosis may behave in a more similar fashion to each other than they do to the group as a whole. In the context of multiple sclerosis it's a particularly important idea, because multiple sclerosis itself is a syndrome, rather than a specific diagnosis established on the basis of a very precisely recognized common disease-causative factor. The importance of stratified medicine in disease in general is that patients with different forms of expression of a syndrome or disease may behave differently with respect to treatments or they have different outcomes. Being able to express the difference in outcomes is important if patients are to balance the benefits and risks of treatment or not treatment. Understanding, which patient group an individual may belong to, can be important in guiding therapy for other reasons too. In the context of multiple sclerosis, specifically, we know that there is a small group of people with multiple sclerosis, who may not show very rapid progression at all, even if untreated, and there's another group, also relatively smaller, will show very malignant progression of multiple sclerosis. And finally, many who occupy middle ground. Deciding on initial treatment, helping people make the decision whether to start treatment or not immediately, and [make the] choice of first treatment - whether it is a traditional first-line medicine or medicine that has higher efficacy but yet has a higher risk profile -
- all can be informed by that initial decision. Personalized Medicine is taking Stratified Medicine one step further: Stratified Medicine tells us about, which class of patients with a given diagnosis we are more like, and something about our general expectations for behavior [disease course]. Personalized Medicine is about trying to individualize this more precisely, to understand how a single given patient is responding or not to medicine or to a management scheme, and to try to help identify medicine that would be most appropriate for that person individually. Currently for multiple sclerosis, the best way we have of doing this for people on or off treatment is to follow them serially with both clinical measures of relapse rate, disability progression, and measures of multiple sclerosis activity, for example, T2 hyperintense lesion count, brain volume change, and assess those who have evidence for no multiple sclerosis disease progression, those who have evidence for modest disease activity, and those who have evidence for higher multiple sclerosis disease activity. That's a way in which we can change whatever our initial management structure is in such a way that it becomes most appropriate for that individual. So that's stratified medicine - going by groups, personalized medicine trying to individualize that for a single person with multiple sclerosis.
Exclusive interview / Dr. Anton Titov MD and Professor Dr. Paul Matthews, leading multiple sclerosis neurologist, neurodegeneration, brain imaging MRI, functional MRI, PET expert and precision medicine specialist.
Neurology disease treatment is very costly and often is not as efficient as it can be. You have advanced the concept of "Stratified Medicine" to improve quality of clinical care for patients with neurological disease. What is Stratified Medicine concept? How does it help in clinical management of neurological diseases, including multiple sclerosis? The concept of stratified medicine is that all patients are not alike, and that some groups of patients who carry a common diagnosis may behave in a more similar fashion to each other than they do to the group as a whole. In the context of multiple sclerosis it's a particularly important idea, because multiple sclerosis itself is a syndrome, rather than a specific diagnosis established on the basis of a very precisely recognized common disease-causative factor. The importance of stratified medicine in disease in general is that patients with different forms of expression of a syndrome or disease may behave differently with respect to treatments or they have different outcomes. Being able to express the difference in outcomes is important if patients are to balance the benefits and risks of treatment or not treatment. Understanding, which patient group an individual may belong to, can be important in guiding therapy for other reasons too. In the context of multiple sclerosis, specifically, we know that there is a small group of people with multiple sclerosis, who may not show very rapid progression at all, even if untreated, and there's another group, also relatively smaller, will show very malignant progression of multiple sclerosis. And finally, many who occupy middle ground. Deciding on initial treatment, helping people make the decision whether to start treatment or not immediately, and [make the] choice of first treatment - whether it is a traditional first-line medicine or medicine that has higher efficacy but yet has a higher risk profile -
- all can be informed by that initial decision. Personalized Medicine is taking Stratified Medicine one step further: Stratified Medicine tells us about, which class of patients with a given diagnosis we are more like, and something about our general expectations for behavior [disease course]. Personalized Medicine is about trying to individualize this more precisely, to understand how a single given patient is responding or not to medicine or to a management scheme, and to try to help identify medicine that would be most appropriate for that person individually. Currently for multiple sclerosis, the best way we have of doing this for people on or off treatment is to follow them serially with both clinical measures of relapse rate, disability progression, and measures of multiple sclerosis activity, for example, T2 hyperintense lesion count, brain volume change, and assess those who have evidence for no multiple sclerosis disease progression, those who have evidence for modest disease activity, and those who have evidence for higher multiple sclerosis disease activity. That's a way in which we can change whatever our initial management structure is in such a way that it becomes most appropriate for that individual. So that's stratified medicine - going by groups, personalized medicine trying to individualize that for a single person with multiple sclerosis.
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